Review of Piracetam – The Godfather of Nootropics

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Piracetam is one of the original nootropic drugs, first developed in 1964. It is the progenitor of racetam compounds, a family of nootropics known primarily for enhancing memory.

When supplemented, this nootropic has two important benefits on the brain. The first effect comes  the modulation of the neurotransmitter glutamate, which heavily involved in cognitive function.2] This has been backed up in EEG studies, where piracetam supplementation was shown to greatly increase brain wave activity.3

This can benefit cognition by improving neuronal communication, especially between the left and right hemispheres of the brain. This often results in more abstract thought, and can be useful for creativity and divergent thinking. Additionally, suppementation was shown to increase  brain activity in the prefrontal cortex, which is responsible for higher-ordered thinking.

Piracetam appears to also increase the brains demand for  acetylcholine, a neurotransmitter primarily known for its ability to enhance learning and This effect seems to occur primarily in the hippocampus, the region of the brain that regulates information processing and memory consolidation.

Piracetam benefits both memory retention and recall, which includes working memory, short-term, and long-term memory.5 These memory-enhancements are further improved when piracetam is stacked with cdp-choline.7


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Piracetam Side Effects

Interestingly, piracetam is remarkably safe, in fact is it less toxic than vitamin C on the body. As such, it is a very popular nootropic due to its relative safety and lack of major side effects.


Piracetam Dosage

While there is no standard dose, the smallest starting dose is considered to be 800mg. Due to the relative safety of this nootropic compound, up to 24g a day can be taken without additional risk of side effects. It’s best to experiment yourself and find the best dose.

It is common for people to stack piracetam with a choline supplement such as alpha-gpc or cdp-choline, since piracetam greatly increases choline usage in the brain.






1. “Piracetam Material Safety Sheet

2. Piracetam Defines a New Binding Site for Allosteric Modulators of α-Amino-3-hydroxy-5-methyl-4-isoxazole-propionic Acid (AMPA) Receptors

3. Effects of nootropics on the EEG in conscious rats and their modification by glutamatergic inhibitors

4. Piracetam diminishes hippocampal acetylcholine levels in rats

5. The effect of piracetam on short- and long-term verbal retrieval in dyslexic boys

6. Effects of piracetam on the performance of rats in a delayed match-to-position task

7. Effects of citicholine and of the combination citicholine + piracetam on the memory (experiments on mice)



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The information on this website has not been evaluated by the Food & Drug Administration or any other medical body. We do not aim to diagnose, treat, cure or prevent any illness or disease. Information is shared for educational purposes only. You must consult your doctor before acting on any content on this website, especially if you are pregnant, nursing, taking medication, or have a medical condition.








An Unbiased Analysis & Review of Qualia Mind by Neurohacker Collective

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Neurohacker Collective is a sophisticated supplement vendor that specializes in creating scientifically formulated nootropic stacks. They were founded in 2015 with the goal of using complex research and development techniques to create world-class products that are backed with high-quality evidence. Their first product created is known as Qualia Mind, designed to optimize brain function in an effective, sustainable, and safe manner.

Rather than relying on cheap ingredients that provide a short-term boost, their products appear to be in carefully created to serve you in the long-term. This means products with 100% transparency over their ingredients and dosages used, without any gimmicky propertiery blends with vague label information.


What is Qualia Mind and Who Can it Benefit?

Supplementation of this product results in five primary benefits:

  • Improved for attention, accuracy, and focus in stressful environments and demanding situations
  • Support for cellular energy production (namely ATP)
  • Enhances neuroplasticity by supporting cell membrane health and cell fluidity, leading to enhanced cellular formation and synaptic activity (neurogenesis & synaptogensis)
  • Supports healhy brain function across all major neurological systems
  • Upregulates the production and signalling of several key neurotransmitters including dopamine, serotonin, and acetylcholine.
  • Improves willpower and focus, heightens creativity
  • Enhances brain nutrition, mental clarity, and lifts brain fog
  • Improves energy and reduces stress-related fatigue


Qualia Mind is unique among nootropic stacks because it is a comprehensive, well-rounded product that can improve brain health and cognitive performance for a very wide audience.

The product contains quite a lot of ingredients (28 in total) with unique qualities and a unique range of carefully selected effects. The properties of these ingredients are such that a syngerstic effect takes places  between them, meaning that the net effect of all these ingredients is greater than the sum of the individual parts.

Interestingly, the serving size actually requires taking 7 capsules in order to get the full dose. The ingredients to not appear to be under-dosed at all, which is very common with most stacks. Many companies like to include as many products as they possibly can without caring much about doses or the quality of ingredients. Neurohacker Collective does not appear to share this sentiment and it would appear that their ingredients serve a real purpose beyond simply looking good on a label.

In short, no matter your age, gender, or background, this product is so well-rounded and powerful for brain health and function that it may be able to help almost anyone.



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What Are the Ingredients?

The 28 vegan gluten-free, non-gmo ingredients include:

  • 6 Nootropic compounds
  • 7 Neuro-vitamins
  • 2 Antioxidants
  • 6 Adaptogen Extracts
  • 5 Amino Acids
  • 2 Choline Donors

qualia mind ingredients

Some key ingredients in this product include PQQ, Phosphatidylserine, DHA, Citicoline, Alpha-GPC Uridine Monophosphate. These ingredients are some of the most well-researched and powerful nootropics that are known in a complex choline-based pathway that enhances neuronal formation and synaptic plasticity. This particular set of ingredients is particularly useful for optimizing memory formation and brain health as we age, and is currently under investigation as a potential treatment for depression and Alzheimer’s Disease.

Other notable ingredients include Coleus forskohlii and Artichoke extract, which are also used for synergistically enhancing synaptic plasticity and long-term potentiation.

This product also contains Mucuna pruriens, N-Acetyl-L-Tyrosine, and DL-Phenylalanine, ingredients which help increase dopamine availability and synthesis.

For highly detailed information on all ingredients contained within this stack, please see this page.

FDA Compliance

The information on this website has not been evaluated by the Food & Drug Administration or any other medical body. We do not aim to diagnose, treat, cure or prevent any illness or disease. Information is shared for educational purposes only. You must consult your doctor before acting on any content on this website, especially if you are pregnant, nursing, taking medication, or have a medical condition.












Alpha Brain Nootropic Stack Review

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Alpha Brain by Onnit is one of the first nootropic stacks to hit the market. It’s considered a tried and true classic nootropic stack with powerful memory-boosting properties. It’s development has inspired many other companies to develop high-quality, well-researched nootropic blends.

Part of the popularity of AlphaBrain is due to the endorsement by Joe Rogan, a popular podcaster and MMA commentator who is known for his experiments with nootropics and other novel psychoactive compounds.

Despite the hype surrounding this nootropic stack, there is strong reason to believe it truly works. It has retained a strong reputation ever since its inception, and many people report very positive experiences from it.




Who Can Benefit From Alpha Brain?

Alpha Brain was developed to rapidly improve mental acuity and eliminate brain fog, leaving the user feeling very sharp and quick. It can enhance memory, especially recollection of names, places, and words, and can improve focus. This can ultimately lead to impressive verbal fluidiy, heightened mental clarity, and enhanced learning ability.

Ultimately, Onnit has developed this stack as a mental performance enhancer that can allow you to beat out your competition. Whether you’re seeking academic, social, or career goals, Alpha Brain may give you the extra 10% you need to fuel your tasks.

See the video below for more information.


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Alpha Brain Ingredients & How it Works

Alph aBrain contains a potent mix of nootropics known for enhancing memory function and brain activity. It should be noted that there are no stimulants such as caffeine in this stack – it only contains tried and true nootropics that have a synergistic effect when combined together.


  • L-Tyrosine is a naturally occuring amino acid which the brain uses to synthesize dopamine and norepinephrine. While L-Tyrosine is present in foods, other amino acids compete for absorption in the gut. As such, supplementation can help maintain optimal mood and cognition.
  • L-Theanine is another naturally-occuring amino acid, commonly found in green and black teas. L-Theanine can increase alpha brain wave activity and enhance attention while also subtly reducing anxiety. It primarily works by modulating glutamate in the brain.
  • Oat Straw is a unique extract that can increase blood flow to the brain by boosting nitric oxide. Preliminary research has found that it may be be able to enhance cognition in healthy people.
  • Phosphatidylserine is a fat-soluble, amino acid compound that is found in the brain. It’s primarily role is to support brain health and cellular membranes. However, this compound is depleted as we age, and as such is a useful prophylactic agent for maintaining healthy brain function.
  • Cat’s Claw is a medicinal plant that is commonly recommended for reducing inflammation and fatigue. It is actually a vine native to the Amazon, and is sometimes referred to as the “rainforest super herb”.
  • Alpha-GPC is a naturally occuring brain nutrient with powerful nootropic properties. Supplementation has shown to significantly enhance acetylcholine in the brain – neurotransmitter which is heavily involved in memory and attention.
  • Bacopa is a nootropic herb that can boost memory and enhance mood. It is also quite effective at preventing inflammation in the brain.
  • Huperzine-A is a plant with powerful nootropic actions. Huperzine-a works by maintaining high levels of acetylcholine for long periods of time, which improves learning and memory. It also helps grow new neurons in the brain.
  • L-Leucine is a branched-chain amino acid (BCAA) that is used by the body to synthesize protein. Supplementation may be able to increase energy levels.
  • Vinpocetine is a synthetic nootropic that can increase oxygen and blood flow to the brain. It may also have antioxidant properties.
  • Pterostilbene is a derivative of resveratrol, an anti-aging compound found in blueberries. There is not much research on it, but it appears to be a very potent antioxidant.















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Alpha Brain Review – Benefits & Side Effects

Alpha Brain is one of the few nootropic stacks that has clinical research behind it. As of 2019 there have been three double-blind, placebo controlled studies specifically conducted to determine its effectiveness.1 So far, all the research has indicated that supplementation can improve memory performance and increase brainwave activity.

One thing to note is that Alpha Brain is actually quite powerful. It’s not something that needs to be taken daily, and is best used for the most demanding days of your week. We suggest taking it no more than twice a week.

There are three key ingredients in Alpha Brain which seem to be doing most of the heavy lifting – Alpha-GPC, Huperzine-A, and Bacopa.


Alpha GPC is a potent nootropic in its own right. Supplementation provides significant amounts of choline to the brain, which is directly converted into the neurotransmitter acetylcholine. Human studies have found supplementation to cause rapid improvements to memory performance.

Huperzine-A contains rare plant alkaloids with shockingly powerful nootropic actions. It’s most known for blocking the enzyme responsible for degrading acetylcholine in the brain, but it doesn’t end there. Supplementation may of huperzine-a increases the activity of three potent neurotrophins (NGF, BDNF, and TGF-β1), which promote the formation and survival of new neurons in the brain. The half-life is 10-14 hours long, which means it may stay active in the brain for over a full day.

Bacopa is a plant that is considered a heavyweight among herbal nootropics. It has considerable memory enhancing potential and may even improve mood. Uniquely, bacopa also raises levels of serotonin and dopamine in the hippocampus – the center of emotional and cognitive processing in the brain.

While these three ingredients do a lot of the heavy lifting, the other ingredients are complementary. When everything is taken as single stack, there does appear to be a synergistic quality that makes it quite powerful indeed.


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FDA Compliance

The information on this website has not been evaluated by the Food & Drug Administration or any other medical body. We do not aim to diagnose, treat, cure or prevent any illness or disease. Information is shared for educational purposes only. You must consult your doctor before acting on any content on this website, especially if you are pregnant, nursing, taking medication, or have a medical condition.