Colouracetam – Side Effects, Doage, Benefits & More

Colouracetam is a fairly new and exotic nootropic that is a part of the racetam family. Like other nootropics of this class, it has a unique pharmacology that makes it a considerably safe memory enhancer and mood brightener.

Colouracetam was developed in 2005 by a major Japanese pharmaceutical company in order to treat cognitive decline in the elderly.

Later it was tested by a US-based biotechnology company in order to treat depression and mood disorders.

Fortunately, it is available as a dietary supplement in the US, and Canada and the UK it is legal to import and possess. However, there are very few nootropic or supplement vendors which sell colouracetam since it is fairly unknown to the general public.

 

 

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Who Can Benefit From Colouracetam?

Colouracetam shares many similar mechanisms and benefits with other racetams, especially its older cousin aniracetam. Some of these benefits include:

 

How Colouracetam Works

Like the others in its class, colouracetam works primarily the acetylcholine system, specifically by increasing the rate of high-affinity choline uptake in the hippocampus. Acetylcholine is a neurotransmitter which regulates learning and memory, and the hippocampus is the primary “processing center” for memory encoding and storage.6https://www.ncbi.nlm.nih.gov/pubmed/7710736

Interestingly, these memory-boosting effects were shown to last for days after administration, showing that it causes persistent benefits to brain function.4https://www.researchgate.net/publication/5392310_MKC-231_a_choline-uptake_enhancer_1_Long-lasting_cognitive_improvement_after_repeated_administration_in_AF64A-treated_rats

Some of these cogntive enhancement may come from colouracetams enhancements of AMPA receptor signalling andĀ  fromneuroprotection against glutamate cytotoxicity3https://www.ncbi.nlm.nih.gov/pubmed/9541286

 

 

Colouracetam Dosage Information

A standard dose is considered to be 20mg taken up to 4 times daily. As colouracetam depletes levels of acetylcholine in the brain, it is highly recommended to take a choline supplement such as cdp-choline to ensure optimal levels of this key neurotransmitter.

 

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References

1. https://www.ncbi.nlm.nih.gov/pubmed/18991809

2. https://www.biospace.com/article/releases/braincells-inc-initiates-phase-2-clinical-trial-with-bci-540-for-depression-with-anxiety-/

3. https://www.ncbi.nlm.nih.gov/pubmed/9541286

4. https://www.researchgate.net/publication/5392310_MKC-231_a_choline-uptake_enhancer_1_Long-lasting_cognitive_improvement_after_repeated_administration_in_AF64A-treated_rats

5. https://www.ncbi.nlm.nih.gov/pubmed/20166767

6. https://www.ncbi.nlm.nih.gov/pubmed/7710736

7. https://www.ncbi.nlm.nih.gov/pubmed/8740080

Phenylpiracetam Review – Phenylpiracetam Dosage Information, Side Effects, Benefits, and More.

Phenylpiracetam is a modified form of the original nootropic Piracetam, containing the addition of a phenyl group to the molecular structure. This simple modification has increased its potency tenfold, allowing it to enter the brain much more efficiency.

Phenylpiracetam is one of the most potent racetam nootropics available today and is used in many different situations. Even small amounts of it can provide a mighty boost to both physical and mental performance. Some major benefits include:

 

 

Who Can Benefit From Phenylpiracetam?

Interestingly, phenylpiracetam was first developed to assist Soviet astronauts in their missions, which were highly cognitively demanding and stressful ordeals. It’s been shown to improve higher brain function while also reducing anxiety, depression, and stress.2https://www.ncbi.nlm.nih.gov/pubmed/16447562

However, after becoming available over the counter as a generic, it has gained considerable attention for its broad range of benefits. It is commonly used nowadays by students, writers, powerlifters, and programmers.

In fact, phenylpriacetam is listed as one of the banned susbstances in the Olympics due to its significant performance-enhancing effects. This is due its ability to enhance psychmotor activity, which is responsible for finesse and intentional actions.2https://www.ncbi.nlm.nih.gov/pubmed/16447562

From concentration and problem solving, and from productivity to memory, Phenylpiracetam causes generalized brain-boosting actions across different cognitive and physical domains. These attributes help establish it as one of the best nootropics on the market.

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What’s the Catch?

Phenylpiracetam has so many benefits, and many people may think it sounds too good to be true.

Interestingly, after reading the current literature and user reports, phenylpiracetam side effects seem quite rare. The only real side effect is sleep difficulty if it is taken at night. Anxiety is relatively uncommon but is possible when high doses.

There is one caveat that we’d like to discuss briefly: Phenylpiracetam loses effectiveness when used repeatedly. We believe this is a positive quality however, as this is a feature that is shared with all other racetam nootropics.

There are virtually zero reported cases of addiction, withdrawal, or dependence. Phenylpiractam is neuroprotective and appears to have self-regulating properties that prevent abuse1https://link.springer.com/article/10.2165/11319230-000000000-00000.

This is a very unique pharmacological property that really sets this nootropic apart from prescription stimulants such as Adderall.

Repeated doses of phenylpiracetam will lose effectiveness very quickly, and even taking higher doses will still cease to work.

Due to this self-regulating feature, we suggest taking phenylpiracetam as-needed. Typically, it is most effective when taken once a week. Taking it every day will quickly stop working, even if higher doses are used. However, it does have neuroprotective and memory-enhancing qualities that may persist even, so daily use may still benefit you.

 

How Does it Work?

Phenylpiractam was shown to enhance alpha and beta EEG activity in the brain and was also shown to reduce seizures and epilepsy.2https://www.ncbi.nlm.nih.gov/pubmed/16447562

It was also shown to provide a moderate boost to dopamine, norepinephrine and GABA in various regions of the brain, which can improve concentration, motivation, and overall mood.3https://link.springer.com/article/10.1134%2FS18197124110200484https://www.sciencedirect.com/science/article/pii/S0091305717301545[/f

 

 

Our Final Thoughts On Phenylpiracetam

In our eyes, phenylpiracetam is the closest thing to a perfect nootropic.

It’s effects are medium-duration, lasting about 6 hours, perfect for enhancing a good chunk of your day without causing insomnia or a “wired” feeling. It’s very unlikely to enduce euphoria or hypomania and as such does not cause unstable mood swings or a “crashing” effect once the substance wears off.

It doesn’t simply make you think you have improved performance, it actually enhances performance in a very real way.

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Phenylpiracetam Dosage Information

Phenylpiracetam is generally dosed once at 100-200mg. However, many people do report they do not feel much of an effect at this range. Some people may need to take up to 400mg to feel an effect. We recommend starting with 200mg first thing in the morning – then taking an additional 100-200mg if they don’t feel anything. It’s best to use it once a week at the most, as taking it more than once a week can noticeably reduce its effectiveness.

Phenylpiracem is best taken with a choline source such as alpha-gpc, as it may rapidly deplete levels of this neurotransmitter.

 

 

References

  1. https://link.springer.com/article/10.2165/11319230-000000000-00000
  2. https://www.ncbi.nlm.nih.gov/pubmed/16447562
  3. https://link.springer.com/article/10.1134%2FS1819712411020048
  4. https://www.sciencedirect.com/science/article/pii/S0091305717301545