Colouracetam is a fairly new and exotic nootropic that is a part of the racetam family. Like other nootropics of this class, it has a unique pharmacology that makes it a considerably safe memory enhancer and mood brightener.
Colouracetam was developed in 2005 by a major Japanese pharmaceutical company in order to treat cognitive decline in the elderly.
Later it was tested by a US-based biotechnology company in order to treat depression and mood disorders.
Fortunately, it is available as a dietary supplement in the US, and Canada and the UK it is legal to import and possess. However, there are very few nootropic or supplement vendors which sell colouracetam since it is fairly unknown to the general public.
Who Can Benefit From Colouracetam?
Colouracetam shares many similar mechanisms and benefits with other racetams, especially its older cousin aniracetam. Some of these benefits include:
- improved working memory and word recall7https://www.ncbi.nlm.nih.gov/pubmed/8740080
- enhanced learning, reading, and writing speed
- promotes nerve cell growth in the brain (neurogenesis)1https://www.ncbi.nlm.nih.gov/pubmed/18991809
- reduced depression, especially for people with treatment-resistant depression2https://www.biospace.com/article/releases/braincells-inc-initiates-phase-2-clinical-trial-with-bci-540-for-depression-with-anxiety-/
- provides long-lasting cognitive enhancements4https://www.researchgate.net/publication/5392310_MKC-231_a_choline-uptake_enhancer_1_Long-lasting_cognitive_improvement_after_repeated_administration_in_AF64A-treated_rats5https://www.ncbi.nlm.nih.gov/pubmed/20166767
How Colouracetam Works
Like the others in its class, colouracetam works primarily the acetylcholine system, specifically by increasing the rate of high-affinity choline uptake in the hippocampus. Acetylcholine is a neurotransmitter which regulates learning and memory, and the hippocampus is the primary “processing center” for memory encoding and storage.6https://www.ncbi.nlm.nih.gov/pubmed/7710736
Interestingly, these memory-boosting effects were shown to last for days after administration, showing that it causes persistent benefits to brain function.4https://www.researchgate.net/publication/5392310_MKC-231_a_choline-uptake_enhancer_1_Long-lasting_cognitive_improvement_after_repeated_administration_in_AF64A-treated_rats
Some of these cogntive enhancement may come from colouracetams enhancements of AMPA receptor signalling and fromneuroprotection against glutamate cytotoxicity3https://www.ncbi.nlm.nih.gov/pubmed/9541286
Colouracetam Dosage Information
A standard dose is considered to be 20mg taken up to 4 times daily. As colouracetam depletes levels of acetylcholine in the brain, it is highly recommended to take a choline supplement such as cdp-choline to ensure optimal levels of this key neurotransmitter.