Oxiracetam Review – An Underrated Nootropic Powerhouse

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Oxiracetam is a nootropic that is part of the original family of racetam compounds, and is often grouped together with its older cousins aniractam and piracetam. These three nootropics are considered to be the first-tiered group of racetams, and share many similarities with one another.


For people who are looking to get into nootropics, this classical racetam family is a very popular starting place due to the relative safety of these compounds. Based on user reports, people tend to have very different experiences with each of the nootropic compounds in this family, despite their structural similarities and mechanisms of action on the brain. There are many discussions comparing these substances ie “aniracetam vs oxiracetam” but ultimately the discussion comes down to individual preferences and differences in brain chemistry.


At first glance, oxiracetam seems to be almost identical to the other two original racetams. When supplemented, it also improves cognitive function and memory by regulating choline and glutamate release in the brain. However, it has two notable differences that help distinguish it from the others quite a lot.



  1. Improves memory by increasing the rate of acetylcholine utilization in the hippocampus and cerebral cortex.1https://www.ncbi.nlm.nih.gov/pubmed/35944552https://onlinelibrary.wiley.com/doi/abs/10.1002/ddr.430280409 However, it appears to stimulate the demand for acetylcholine even more than piracetam or aniracetam.
  2. Increases brain activity through modulation of glutamate via AMPA receptors. However, this effect appears to be strong enough to long-term potentiation (LTP) in the brain. In a nutshell, LTP is a persistent strengthening of brain cell connections that is based on recent behavior or information. It is strongly implicated in memory and learning.3https://www.ncbi.nlm.nih.gov/pubmed/2564640


In summation, it would appear that oxiracetam is a potent racetam that can greatly improve memory and learning by influencing brain processes directly involved in memory encoding, storage, and retrieval processes. It appears to strongly modulate activity in the hippocampus, the region of the brain primarily responsible for memory and information processing.

is often classified as a mild stimulant as well, though the effect is fairly subtle and does not result in any CNS stimulation.


Oxiracetam Dosage

A standard dose is considered to be 800mg, typically taken two or three times daily. Side effect profile is very minimal and is mostly limited to sleep disturbances when taken late at night. Headaches are another common side effect, which occur due to depleted levels of choline in the brain. As such, it is highly recommended to supplement cdp-choline or alpha-gpc when taking oxiracetam.


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1. Effect of oxiracetam and piracetam on central cholinergic mechanisms and active-avoidance acquisition

2. Oxiracetam and aniracetam increase acetylcholine release from the rat hippocampus in vivo

3. Temporally distinct pre- and post-synaptic mechanisms maintain long-term potentiation




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