Piracetam is one of the original nootropic drugs, first developed in 1964. It is the progenitor of racetam compounds, a family of nootropics known primarily for enhancing memory.
When supplemented, this nootropic has two important benefits on the brain. The first effect comes the modulation of the neurotransmitter glutamate, which heavily involved in cognitive function.2https://pubs.acs.org/doi/abs/10.1021/jm901905j/f] This has been backed up in EEG studies, where piracetam supplementation was shown to greatly increase brain wave activity.3https://www.sciencedirect.com/science/article/abs/pii/S0361923011000773.
This can benefit cognition by improving neuronal communication, especially between the left and right hemispheres of the brain. This often results in more abstract thought, and can be useful for creativity and divergent thinking. Additionally, suppementation was shown to increase brain activity in the prefrontal cortex, which is responsible for higher-ordered thinking.
Piracetam appears to also increase the brains demand for acetylcholine, a neurotransmitter primarily known for its ability to enhance learning and memory.4www.sciencedirect.com/science/article/pii/0024320581906858 This effect seems to occur primarily in the hippocampus, the region of the brain that regulates information processing and memory consolidation.
Piracetam benefits both memory retention and recall, which includes working memory, short-term, and long-term memory.5https://www.ncbi.nlm.nih.gov/pubmed/35225106https://www.ncbi.nlm.nih.gov/pubmed/9533177 These memory-enhancements are further improved when piracetam is stacked with cdp-choline.7https://www.ncbi.nlm.nih.gov/pubmed/2392950
Piracetam Side Effects
While there is no standard dose, the smallest starting dose is considered to be 800mg. Due to the relative safety of this nootropic compound, up to 24g a day can be taken without additional risk of side effects. It’s best to experiment yourself and find the best dose.
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